Amelioration of aminoglycoside nephrotoxicity requires protection of renal mitochondria
نویسندگان
چکیده
منابع مشابه
Aminoglycoside nephrotoxicity
Aminoglycoside are frequently used due to its high efficacy against gram-negative bacteria and positive synergism with other antibiotics against gram-positive organisms. They are commonly used for prevention and treatment of infection complications after cardiothoracic surgery. The principal side effect of this class of antibiotics is nephrotoxicity, which may occur in up to 20% of the exposed ...
متن کاملProtection of renal tubules against gentamicin induced nephrotoxicity
*Corresponding author: Dr. Majid Tavafi, Department of anatomy, Faculty of Medicine, Lorestan University of Medical sciences, Khoram Abad, Iran. E-mail: [email protected] I spite of undesirable gentamicin nephrotoxicity, this antibiotic is commonly used versus Gram-negative bacteria and still constitutes the only effective therapeutic alternative against microorganisms-pseudomonas, proteus and ...
متن کاملAminoglycoside nephrotoxicity: modeling, simulation, and control.
The main constraints on the administration of aminoglycosides are the risks of nephrotoxicity and ototoxicity, which can lead to acute, renal, vestibular, and auditory toxicities. In the present study we focused on nephrotoxicity. No reliable predictor of nephrotoxicity has been found to date. We have developed a deterministic model which describes the pharmacokinetic behavior of aminoglycoside...
متن کاملMegalin deficiency offers protection from renal aminoglycoside accumulation.
Aminoglycosides are antibiotics commonly used to treat life-threatening Gram-negative bacterial infections. However, their use is hampered by their severe nephrotoxicity due to accumulation in renal proximal tubules. Several pathways have been implicated in the renal uptake of aminoglycosides including megalin, an endocytic receptor in proximal tubular cells. Here, we have used mouse models wit...
متن کاملTitle : Aminoglycoside Nephrotoxicity: Modeling, Simulation and Control
Address: (1) ADCAPT, Service Pharmaceutique, Hôpital Antoine Charial, Francheville, France. (2) Université Paris−Sud, Laboratoire des Signaux et Systèmes (CNRS−SUPELEC), Gif−sur− Yvette, France. (3) INRETS, Bron, France. (4) Laboratoire GAGE, Ecole Polytechnique, Palaiseau, France. (5) Laboratory of Applied Pharmacokinetics, University of Southern California, School of Medicine, Los Angeles CA ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2010
ISSN: 0085-2538
DOI: 10.1038/ki.2010.20